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Bulbine capitata Poelln.

Protologue
Feddes Repert. 53: 37 (1944).
Family
Asphodelaceae
Origin and geographic distribution
Bulbine capitata is native to Namibia, Botswana, Zimbabwe, Swaziland, Lesotho and South Africa.
Uses
In Botswana a root decoction of Bulbine capitata is applied to the skin to cure rashes and sexually transmitted diseases. In Lesotho it is taken orally as a mild purgative and to cure gonorrhoea.
Production and international trade
In local markets in Botswana both roots and leaves of Bulbine capitata are sold for medicinal use.
Properties
Anthraquinones, phenylanthraquinones and isofuranonaphthoquinones have been isolated from the roots and leaves of Bulbine capitata. Several isofuranonaphthoquinones from the roots showed antioxidant activity in a human lipoprotein oxidation assay, some of them with activity comparable to that of quercetin, a flavonoid with established antioxidant activity. These compounds also demonstrated weak antiplasmodial activities in vitro. Bulbine capitata is said to have antibiotic and antipyretic properties, but these remain unsubstantiated.
Botany
Tufted, perennial herb up to 45 cm tall, with rhizome up to 5 cm Χ 1 cm. Leaves in a basal rosette, simple, erect to arching, without stipules and petiole, up to 25 cm Χ 2 mm, fleshy, at base extending into a tubular sheath, old leaf bases persistent. Inflorescence a terminal, densely flowered raceme 2–15 cm long; peduncle up to 25 cm long; bracts ovate, 2–10 mm long, auricled, persistent. Flowers bisexual, regular, 3-merous; pedicel up to 20 mm long at flowering, 35 mm in fruit; tepals 6, oblong-ovate, c. 7 mm Χ 3 mm, 1-veined, yellow; stamens 6, c. 6 mm long, densely bearded in upper third; ovary superior, 3-celled, style terete, stigma head-shaped. Fruit an ovoid capsule c. 7 mm long, dehiscing loculicidally, brown to black, many-seeded. Seeds pyramidal, 2–3 mm long, brownish black.
Bulbine comprises about 60 species, most of them restricted to southern Africa. Bulbine narcissifolia Salm-Dyck, a native of Botswana, South Africa and Lesotho, has several medicinal uses in South Africa. The fresh leaf sap is applied to wounds to promote healing, as a wart and corn remedy, and to cure ringworm and rash. A cold infusion of the leaves is used as a purgative. A decoction of the roots is taken to relieve rheumatic pain and to induce pregnancy. In southern Africa Bulbine capitata flowers in spring.
Ecology
Bulbine capitata grows in scattered clumps in open grassland and thorn scrub on sandy soil and on rocky hillsides at about 1000 m altitude.
Management
Bulbine capitata is only harvested from the wild.
Genetic resources and breeding
There are no reports on threats to Bulbine capitata and harvesting of rhizomes is probably sustainable. Once demand for rhizomes increases the wild populations may need protection.
Prospects
The chemistry of Bulbine capitata has been the subject of in-depth studies. The potential of the isolated isofuranonaphthoquinones in the development of antimalarial drugs, as well as in the development of coronary artery disease, in which the oxidation of lipoproteins is thought to play a critical role, deserves more research attention.
Major references
• Abegaz, B.M., Ngadjui, B.T., Bezabih, M. & Mdee, L.K., 1999. Novel natural products from marketed plants of eastern and southern Africa. Pure and Applied Chemistry 71(6): 919–926.
• Bezabih, M., Abegaz, B.M., Dufall, K., Croft, K., Skinner-Adams, T. & Davis, T.M.E., 2001. Antiplasmodial and anti-oxidant isofuranonaphthoquinones from the roots of Bulbine capitata. Planta Medica 67: 340–344.
• Bezabih, M., Motlhagodi, S. & Abegaz, B.M., 1997. Isofuranonaphthoquinones and phenolic and knipholone derivatives from the roots of Bulbine capitata. Phytochemistry 46(6): 1063–1067.
• Kativu, S., 2001. Asphodelaceae. In: Pope, G.V. (Editor). Flora Zambesiaca. Volume 12, part 3. Royal Botanic Gardens, Kew, Richmond, United Kingdom. pp. 25–48.
• Majinda, R.R.T., Abegaz, B.M., Bezabih, M., Ngadjui, B.T., Wanjala, C.C.W., Mdee, L.K., Bojase, G., Silayo, A., Masesane, I. & Yeboah, S.O., 2001. Recent results from natural product research at the University of Botswana. Pure and Applied Chemistry 73(7): 1197–1208.
Other references
• Bezabih, M. & Abegaz, B.M., 1998. 4’-Demethylknipholone from aerial parts of Bulbine capitata. Phytochemistry 48(6): 1071–1073.
• Bringmann, G., Menche, D., Bezabih, M.-T., Abegaz, B.M. & Kaminsky, R., 1999. Antiplasmodial activity of knipholone and related natural phenylanthraquinones. Planta Medica 65(8): 757–758.
• Qhotsokoane-Lusunzi, M.A. & Karuso, P., 2001. Secondary metabolites from Basotho medicinal plants. I. Bulbine narcissifolia. Journal of Natural Products 64: 1368–1372.
• van Jaarsveld, E. & Forster, P.I., 2001. Asphodelaceae. In: Eggli, U. (Editor). Illustrated handbook of succulent plants: Monocotyledons. Springer Verlag, Berlin, Germany. pp. 232–246.
• Watt, J.M. & Breyer-Brandwijk, M.G., 1962. The medicinal and poisonous plants of southern and eastern Africa. 2nd Edition. E. and S. Livingstone, London, United Kingdom. 1457 pp.
Author(s)
• C.H. Bosch
PROTA Network Office Europe, Wageningen University, P.O. Box 341, 6700 AH Wageningen, Netherlands


Editors
• G.H. Schmelzer
PROTA Network Office Europe, Wageningen University, P.O. Box 341, 6700 AH Wageningen, Netherlands
• A. Gurib-Fakim
Faculty of Science, University of Mauritius, Rιduit, Mauritius
Associate editors
• C.H. Bosch
PROTA Network Office Europe, Wageningen University, P.O. Box 341, 6700 AH Wageningen, Netherlands
• M.S.J. Simmonds
Royal Botanic Gardens, Kew, Richmond, Surrey TW9 3AB, United Kingdom
• R. Arroo
Leicester School of Pharmacy, Natural Products Research, De Montfort University, The Gateway, Leicester LE1 9BH, United Kingdom
• A. de Ruijter
PROTA Network Office Europe, Wageningen University, P.O. Box 341, 6700 AH Wageningen, Netherlands
General editors
• R.H.M.J. Lemmens
PROTA Network Office Europe, Wageningen University, P.O. Box 341, 6700 AH Wageningen, Netherlands
• L.P.A. Oyen
PROTA Network Office Europe, Wageningen University, P.O. Box 341, 6700 AH Wageningen, Netherlands

Correct citation of this article:
Bosch, C.H., 2006. Bulbine capitata Poelln. In: Schmelzer, G.H. & Gurib-Fakim, A. (Editors). Prota 11(1): Medicinal plants/Plantes mιdicinales 1. [CD-Rom]. PROTA, Wageningen, Netherlands.